The revised International Health Regulations (IHR) entered into force on 15 June 2007. In accordance with this new international treaty, every member state of the World Health Organization has been given five years in which to review their existing health systems and structures, and where necessary, improve their capacity for the detection, reporting, assessment of, and response to public health emergencies of international concern. Of course, for developed countries, it is unlikely that establishing and maintaining these core capabilities will be difficult. For many less developed countries, however, the revised IHR obligations pose a challenge on a number of fronts. This article explores some of the challenges that less developed countries face in meeting their new IHR obligations prior to discussing the role that the Australian government can play in assisting its Asia-Pacific neighbours achieve these measures. © 2009 Australian Institute of International Affairs.