It is widely recognised that the adverse impacts that transnational forces are having on health determinants and outcomes require more effective collective action. The Asian region has been among the most acutely affected by the health impacts of globalisation, while many health issues in the region have potentially far reaching consequences. The rapidly rising economic status of many Asian countries, coupled with their vulnerability to global health, points to the need to better understand their contributions to Global Health Governance (GHG). This article analyses Asian contributions to three key instruments underpinning GHG - the International Health Regulations (IHR), Pandemic Influenza Preparedness Framework (PIPF), and Framework Convention on Tobacco Control (FCTC). It finds that, if Asian countries are to move, from rule takers to rule makers, there is a need to address weak capacity in the region, to go beyond traditional notions of sovereignty, and to build trust and policy processes across the region.© 2012 London School of Economics and Political Science and John Wiley & Sons Ltd.